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Xeomin vs. Botox; Which One Should I Choose?

If you are interested in different methods of treating wrinkles, you have definitely heard the names Botox and Xeomin. But, when comparing Xeomin vs. Botox, which one is the best solution? We are here to talk about both of these injectables and help you choose between the two.


What Is Botox?

Botox is a very popular injectable that treats fine lines and wrinkles. But its benefits are not limited to cosmetic services. It also treats migraines, excessive sweating, and overactive bladder. As a matter of fact, FDA first approved it for treating medical conditions, and 15 years later, it was approved for cosmetic use.


What Is Xeomin?

Xeomin is also an injectable used for treating wrinkles and fine lines. It is considered a refined version of botulinum toxin A and doesn’t contain preservative proteins like Botox. However, it is not used as widely as Botox around the world.


How Do These Injectables Work?

Botox and Xeomin work similarly in that they both have botulinum toxin A as their active ingredient. When this toxin is injected into a muscle, it blocks the neurotransmitters and stops the muscle from contracting. So, it can relax the muscle causing a wrinkle. Don’t forget that these injectables work best on a dynamic wrinkle: frown lines, smile lines, crow’s feet, etc.



Xeomin vs. Botox; What Are the Differences?

Though Xeomin and Botox have similar functions and results, they still differ in some other criteria. Here are the main differences between Botox and Xeomin:


Injection Site

Compared with Xeomin, Botox is generally approved to be injected into more areas. Xeomin got FDA approval for wrinkles between the eyebrows in 2010. However, Botox is used not only between eyebrows but also for forehead lines, crow’s feet, and even treating migraines.



As mentioned earlier, Botox and Xeomin have the same active ingredient, but differ in other ingredients. Botox has added proteins that might cause an allergic reaction in lactose-intolerant patients. Xeomin is the refined version of botulinum toxin type A.



Dosage units may differ between Botox and Xeomin depending on the injection site. For example, 20 units of Xeomin or Botox is enough for frown lines. However, you might need 24 or 40 units of Botox to target crow’s feet.



Although the final cost of the procedure depends on the number of injection sites and units needed, Xeomin is less expensive per unit. Unfortunately, insurance doesn’t cover these injectables as they are considered a cosmetic procedure. You should take this into account when making a decision.


All in One Look

In the table below you can see the main differences between Botox vs. Xeomin in one look:


Xeomin Botox

Generic Name



Injection Site

Glabellar Lines & Abnormal Muscle Contractions

Glabellar Lines, Migraines, Overactive Bladder, …


A Refined Version of Botulinum Toxin Type A

Botulinum Toxin Type A with Added Preservative Proteins


20 Units for Frown Lines

Depends on the Site of Injection

Cost Usually Cheaper than Botox

More Expensive than Xeomin


Is Xeomin Better Than Botox?

The answer to this question depends on what you have in mind. For example, the answer is yes if you want to treat your frown lines, are lactose-intolerant, or have built up resistance against Botox. Xeomin can be more effective for you since it doesn’t contain accessory proteins. It takes effect faster, and you won’t have any allergic reactions.


How Long Does Xeomin Last? Does It Last Longer Than Botox?

Studies have shown no difference in the lasting power of these two injectables. Sometimes Xeomin even lasts longer than Botox when it comes to treating glabellar lines. They both generally last three to four months.


Can You Mix Botox and Xeomin?

We are afraid you can’t mix these toxins, as doing so might result in dangerous side effects. We recommend that you consult a certified doctor about Botox vs. Xeomin if you can’t decide which option is best for you.


Final Verdict

In this article, we talked about the differences and similarities between Xeomin vs. Botox. If you want to know more about Xeomin or Botox, and reside in the Los Angeles area, we recommend you get an appointment at Beverly Willshire Aesthetics.

Dr. Zarrini and his team of specialists have a great record of successful Botox and Xeomin applications, and they can guide you through every step of the procedure so you can get exactly what you want.




  • Can I use Xeomin or Botox while pregnant?

Generally, you are advised against using these injectables while pregnant or nursing. You can consult with your doctor about your specific case.


  • Can I use Xeomin or Botox with alcohol?

Alcohol or any other blood-thinning substance worsens the side effects of your procedure. So, generally, it is advised to hold off alcohol consumption for at least a day after your Xeomin or Botox procedure.


  • Can Xeomin and Botox injections be repeated?

Of course, you can get any of these injectables every 3 or 4 months.